Studies of Rearrangement Reaction. VIII. Ring-Contraction from Pyridazinone Derivatives to Pyrazolone Derivatives. (3).
نویسندگان
چکیده
منابع مشابه
Synthesis and Anticonvulsant Activity of Pyridazinone Derivatives
In the recent years there has been an increased interest in the pyridazinone ring system. Many investigations indicated that the presence of at least one aryl group, one or two electron donor atoms and/or an NH group in a special spatial arrangement is necessary for anticonvulsant activity. Many investigations indicated that the presence of at least one aryl group, one or two electron donor ato...
متن کاملDocking and quantitative structure–activity relationship of bi-cyclic heteroaromatic pyridazinone and pyrazolone derivatives as phosphodiesterase 3A (PDE3A) inhibitors
PDE3s belong to the phosphodiesterases family, where the PDE3A isoform is the major subtype in platelets involved in the cAMP regulation pathway of platelet aggregation. PDE3A inhibitors have been designed as potential antiplatelet agents. In this work, a homology model of PDE3A was developed and used to obtain the binding modes of bicyclic heteroaromatic pyridazinones and pyrazolones. Most of ...
متن کاملSynthesis and biological evaluation of some new pyridazinone derivatives.
A series of pyridazinone derivatives (19-34) were synthesized with an aim to synthesize safer anti-inflammatory agents. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation (LPO) actions. The percentage inhibition in edema at different time intervals indicated that compounds 20, 26, 28 and 34 exhibited good anti-inflammatory potential, comparab...
متن کاملNew pyrazolone derivatives synthesis: comparison of the catalytic effect of three typically different Brønsted acid catalysts on the reaction progression
Via the one-pot condensation reaction of ethyl acetoacetate, aromatic aldehydes, 2,4-dinitrophenylhydrazine, and β-naphthol; new pyrazolone derivatives were synthesized in the presence of three Brønsted acid catalysts. These Brønsted acid catalysts are Silica sulfuric acid (SSA), tetra-n-butyl ammonium hydrogen sulfate (TBAHSO4) and [2,2′-Bipyridine]-1,1′-diium tricyanomethanide {[2,2′-BPyH][C(...
متن کاملSpectral Studies of Azo Pyrazolone Derivatives Complexes with Some Transition Metals
The discharge of effluents from material ventures has been a noteworthy worry of the cutting edge world because of the colossal contamination that these effluents advance on the water assets. Among the engineered colors discharged in effluents from material ventures, azo dyes are a standout amongst the most unfavorable classes since it is exceedingly determined in the oceanic environment, becau...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1964
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.12.176